摘要
4,4-二(4-氟苯基)丁酸为一重要医药中间体。以4-(4-氟苯基)丁内酯和氟苯为原料,经Feriedel-Crafts反应制备,常因各种条件的影响而改变产物的异构体比例。本文应用磺化反应成功地对4,4-二(4-氟苯基)丁酸中的邻位异构体进行了分离,取得了满意的效果,达到了纯化产品之目的。
4,4-Bis(4-fluorophenyl) butanoic acid is an important pharmaceutical intermediate. It is usually prepared by Friedel-Crafts reaction of 4-(4-fluorophenyl) butyrolactone with fluorobenzene. But the ratio of products is often affected by reaction conditions. By applying sulfonation, the undesired isomer can be successfully removed.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第8期590-592,共3页
Acta Pharmaceutica Sinica
关键词
丁酸
邻位异构物
磺化
分离
4,4-Bis(4-fluorophenyl)butanoic acid
Ortho-isomer
Sulfonation