手足口病再次感染的流行病学特征分析

Analysis for the epidemiological characteristics of reinfected cases of hand - foot - mouth disease

目的分析手足口病再次感染的发生率及流行病学特征，为手足口病防控提供科学依据。方法利用《中国疾病监测信息报告管理系统》手足口病个案资料，采用描述性流行病学方法进行分析。结果在河南省2008年至2010年发生的210175例手足口病患儿中，有1627例发生2次及以上感染，发生率为7．74‰，在1627例再次感染人群中男女性别为2．07：1；发病年龄主要集中在1～3岁（占91．76％）；再次感染高峰期与全省总发病高峰期相一致，约80．76％的再次感染病例发生在距首次感染后的1年内，实验室诊断病例占再次感染病例的6．27％，实验室诊断证实同一患儿两次感染为不同型别病毒。结论儿童可多次感染手足口病，1～3岁幼儿仍是重点防护人群。

Objective To analyze the reinfection rate and epidemiological characteristics of hand -foot -mouth disease（ HFMD）, and then provide scientific evidence for the prevention and control of HFMD. Methods The data of HFMD cases in Henan was collected from national diseases reporting information system and was analyzed by descriptive epidemiological methods. Results 1627 HFMD cases were attacked twice and more among 210175 cases in henan between 2008 and,2010 and the reinfec- tion rate was 7.74%0. The sex ratio （ male ： female） of reinfection was 2.07： 1. 91.76 percent of reinfec- ted cases＇ age of onset was between 1 and 3. The peak time of reinfection was the same as the peak time of incidence of HFMD. 80.76 percent of reinfection occurred in one year after the first infection. 6.27 percent of the reinfected cases were diagnosed by the laboratory. The virus type of first infection and reinfection for one same case were different. Conclusions There might be more than once incidence of HFMD for children, and the 1 -3 years old children were still key protected population.