双水平气道正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床研究

Clinical application of bilevel positive air pressure ventilation on chronic obstructive pulmonary disease complicated with respiratory failure

目的观察双水平气道正压（BiPAP）通气治疗慢性阻塞性肺疾病（COPD）合并呼吸衰竭的临床疗效。方法选取均给予常规治疗的120例COPD合并呼吸衰竭患者随机分为两组，其中治疗组60例，同时采用Bi．PAP通气治疗。观察两组患者治疗前后动脉血气（ABG）指标变化以及病死率。结果治疗组住院病死率下降，血气指标改善，与对照组比较差异有统计学意义。结论BiPAP通气是治疗COPD合并呼吸衰竭的有效方法，其能迅速改善ABG指标，降低病死率。

Objective To investigate the clinical effect of bilevel positive air pressure （BiPAP） ventilation on chronic obstructive pulmonary disease（ COPD ） complicated with respiratory failure. Methods One hundred and twenty patients with COPD complicated with respiratory failure, received the conventional therapies, were randomized into two groups. At the same time, 60 patients in the treatment group were treated with BiPAP ventilation. Arterial blood gas （ABG） , the inhospital mortality and reac- tion were investigated. Results BiPAP ventilation increased PaO2, declined PaCO2, delevated blood pH, and decreased the inhospital mortality, compared with the patients in the control group, the difference was significant （ P 〈0. 05 or P 〈 0.05 ） , and without any reaction. Conclusions BiPAP ventilation is effective for COPD patients with respiratory failure. It can improve ABG rapidly, decrease inhospital mortality.