杜衡的抗过敏成分

ANTIANAPHYLACTIC COMPONENTS OF ASARUM FORBSII MAXIN

从马兜铃科植物杜衡(Asarum forbesii Maxin)的醋酸乙酯提取物中分得七个成分,经光谱分析和化学反应鉴定为3 S-苯甲酰氧-2S-羟基-2-异丙基丁酸甲酯(Ⅰ);2R-苯甲酰氧异戊酸甲酯(Ⅱ);2R-肉桂酰氧异戊酸甲酯(Ⅲ);2R-胡椒酰氧异戊酸甲酯(Ⅳ);榄香素(Ⅴ);反式细辛脑(Ⅵ);亚油酸(Ⅶ)。化合物Ⅰ,Ⅱ,Ⅲ和Ⅳ为新化合物,分别命名为杜衡素(asarumin)A,B,C和D。其中Ⅰ,Ⅱ,Ⅲ和Ⅶ对大鼠被动皮肤过敏具有抑制作用。

From the ethyl acetate extract of Asarumforbesii Maxin, four new constituents, asarumin A(Ⅰ), B(Ⅱ), C(Ⅲ) and D(Ⅳ), were isolated along with elemicin (Ⅴ), trans-asarone(Ⅵ) and linoleic acid(Ⅶ). The structures of the new compounds were elucidated as. methyl 3S-benzoyloxy-2S-hydroxy-2-isopropylbutyrate for Ⅰ, methyl 2R-benzoyloxyisopentanoate for Ⅱ, methyl 2R-trans-cinnamoyloxyisopentanoate for Ⅲ and methyl 2R-piperonyloyloxyisopentanoate for Ⅳ. Compounds Ⅰ, Ⅱ, Ⅲ and Ⅶ showed weak inhibition of PCA in rats, but the other compounds were inactive.