3-甲基芬太尼衍生物的合成及镇痛活性

SYNTHESIS AND ANALGESIC ACTIVITY OF THE DERIVA TIVES OF 3-METHYL FENTANYL

本文合成了6个1-取代-3-甲基芬太尼衍生物。初步的药理实验结果表明,它们均具有典型的吗啡样作用。某些1位β-取代乙烯基乙基衍生物有强镇痛活性。简要地讨论了其结构—活性关系。

Six analogues of 1-substituted-3-methylfentanyl were synthesized. All of them are liquid compounds. Preliminary pharmacological results sliowed that some compounds of 1-β-substituted vinylethyl-3-methyl derivatives of fentanyl have strong analgesic activity with typical morphine-like action.Structure-activity relationships are briefly discussed.