摘要
于摘除心脏前1 h或4 h给予DSPM 5 mg╱kg,可预防大鼠离体心脏的缺血损伤,使缺血后恢复灌流的心脏心功能有显著恢复,尤以4h前用DSPM者更明显,DSPM 1.5～6mg╱kg可显著对抗Iso引起的小鼠心肌钙含量增加,6mg╱kg 还可减少正常心肌钙含量。提示DSPM有保护缺血心肌的作用,此作用可能与其钙拮抗作用有关。
ip DSPM 5 mg/kg 1 or 4 h before excision of the heart was found to preyent damage to the heart due to global myocardial ischemia. Compared with the controls, the heart rate, coronary resistance, contractile force and edema of the heart were all greatly improved during the 60 min reflow after 25 min of no-flow, especialy the heart pretreated with DSPM 4 h prior to excision. In addition, DSPM 1.5, 6 mg/kg markedly reduced the myocardial Ca^(2+) content measured by isoproterenol in mice. DSPM at higher dosage also lowered the normal myocardial Ca^(2+) content. These results suggest that DSPM may have a protective effect on myocardial ischemia which might be associated with its calcium antagonistic action.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第11期807-810,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
心肌缺血
钙拮抗剂
碘化甲基吡啶
2- [ p- (dimethylamino) styryl] pyridine methiodide (DSPM)
Myocardial ischemia
Calcium antagonists
isoproterenol
verapamil
