应用导数光谱法考察苯呋洛尔溶液体外经皮渗透性

USE OF DERIVATIVE UV SPECTROSCOPY TO MONITOR THE PERCUTANEOUS ABSORPTION OF BEFUNOLOLHCL

本文应用二阶导数紫外分光光度法考察了苯呋洛尔溶液体外经皮渗透性。考察了促进剂月桂氮(?)酮-丙二醉及PEG-400溶剂对其渗透性的影响。应用二阶导数紫外分光光度法消除了兔皮溶出物对一般紫外测定方法的干扰。结果表明:苯呋洛尔溶液具有体外经皮渗透性;月桂氮(?)酮-丙二醇系统及PEG-400均能增强苯呋洛尔溶液的体外经皮渗透性。

Second-order derivative UV spectroscopy was used to measure the transfer of befunolol - HCl across full - thickness rabbit skin in vitro. The effect of penetration enhancers, azone-PG and PEG-400, on permeation course of befunolol-HCl was studied. A type of horizontal diffusion cell was employed. Permeability coefficients were measured in normal saline and in solutions containing the enhancing agents. The results indicated that befunolol - HCl may be an interesting candidate for transdermal administration and azone-PG highly and significantly increases the skin permeation of the drug in the solvent System tested.