雷酚内酯的结构修正

STRUCTURE REVISION OF TRIPTOPHENOLIDE

雷公藤别名黄藤,系卫矛科植物雷公藤(Tripterygium wilfordii Hook.f.)。其根有舒筋活血,祛风湿,消肿止痛的功效,多用于类风湿关节炎的治疗。根皮中含有生物碱、甙、萜以及其它成分。

A diterpenoid-lactone, white thin crystals, C_(20)H_(24)O_3, m/z: 312 (M^+), mp 222～223℃, UVλ_(max) (EtOH)217 (logε4.36)nm, has been isolated from the ethyl acetate extract of the roots of Tripterygium wilfordii Hook. f., in a yield of 0.025‰. Its structure was elucidated by spectral analysis(UV, IR, MS, ~1HNMR and ^(13)CNMR) and X-ray SCD. It is the known triptophenolide with revision of structure.Triptophenlolide was shown to have obvious inhibiting effects on lymphocyte and IgG (P<0.01) when mice and rats were given ig 1.5 mg/kg. The total complements in blood serum was increased. When BALB/C mice were given ig 1.5 mg/kg, the ear oedema induced-by dimethyl benzene was significantly inhibited (P<0.01); The ear oedema induced by croton oil in SD rats at a dose of ig 1.0 mg/kg was also significantly inhibited (P<0.05). The vitamine C content of the adrenal gland was reduced in mice at a dose of 1.5 mg/kg. The ig LD_(50) of triptophenolide was greater than 30mg/kg.