辛伐他汀对脓毒症大鼠肝功能的影响被引量：1

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摘要目的观察辛伐他汀预处理大鼠行盲肠结扎及穿孔制作脓毒症模型后肝脏酶学的变化。方法对Wistar大鼠按辛伐他汀20 mg.kg-1.d-1的剂量干预14 d后行盲肠结扎及穿孔建立脓毒症模型,按照6、24 h和48 h分别留取血液标本,应用ELISA的方法检测血清谷胱甘肽硫转移酶(GST)及谷氨酸脱氢酶(GLDH)水平。结果脓毒症模型大鼠血清GST及GLDH水平随时间进行性增高,辛伐他汀预处理后脓毒症大鼠血清GST及GLDH水平升高幅度明显下降(P<0.05)。结论辛伐他汀对脓毒症大鼠肝功能损伤具有一定程度保护作用。

作者赵鹤龄陆鹏

机构地区河北省人民医院重症医学科河北医科大学第一医院重症医学科

出处《中国老年学杂志》 CAS CSCD 北大核心 2011年第19期3770-3771,共2页 Chinese Journal of Gerontology

关键词辛伐他汀脓毒症盲肠结扎穿孔谷氨酸脱氢酶谷胱甘肽硫转移酶

分类号 R969 [医药卫生—药理学]

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