1Sly RM, Changing prevalence of allergic rhinitis and asthma, Ann Allergy Asthma Immunol, 1999, 82 (3) : 233-252.
2Stmehan D. Hay fever, hygiene and household size. BMJ, 1989, 299 (6710) : 1259-1260.
3Gereda JE, Leung DY, Thatayatikom A, et al. Relation between house-dust endotoxin exposure,type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet, 2000, 355 (9216): 1680-1683.
4O' Garra A, Vieira E Regulatory T cells and mechanisms of immune system control. Nat Med, 2004, 10 (8) : 801-805.
5Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of foxp3. Nat Genet, 2001, 27 (1) : 20-21.
6Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4^+CD25^+ regulatory T cells. Nat Immunol, 2003, 4 (4): 330-336.
7Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Lrnmunol, 1995 (3), 155: 1151-1164.
8Ling EM, Smith T, Nguyen XD, et al. Relation of CD4^+CD25^+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet, 2004, 363 (9409) : 608-615.
9Xu G, Mou Z, Jiang H, et al. A possible role of CD4^+CD25^+ T cells as well as transcription factor Foxp3 in the dysregulation of allergic rhinitis. Laryngoscope, 2007, 117 (5) : 876-880.
10Akidis M, Verhagen J, Taylor A, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergic-specific T regulatoryl and T helper 2 cells. J Exp Med, 2004, 199 (11) : 1567-1575.
4Jacobsen L, Niggemann B, Dreborg S, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial astbma:10-year follow --up on the PAT study[J]. Allergy,2007,62(8) :943- 948.
