甘精胰岛素联合阿卡波糖治疗老年2型糖尿病患者的疗效与安全性

Curative Effect and Safety of Insulin Glargine Combined with Acarbose on Treatment Senile Type Ⅱ Diabetes

目的观察甘精胰岛素注射液联合口服降糖药物阿卡波糖对老年2型糖尿病患者的血糖控制情况和低血糖风险。方法选择口服降糖药物血糖控制不良的老年2型糖尿病患者60例,随机分为甘精胰岛素组(简称甘精组)和预混胰岛素优泌林70/30组(简称预混组),每组各30例。甘精组:在每天3餐前口服阿卡波糖的基础上,于22:00注射甘精胰岛素1次;预混组:每天早、晚餐前分别注射优泌林70/30预混胰岛素,根据空腹及餐后血糖水平,每3 d调整阿卡波糖及胰岛素剂量,以空腹血糖<7.2 mmol/L,餐后血糖<10.0 mmol/L为治疗目标,共治疗16周,观察血糖控制和低血糖发生情况。结果治疗后,两组HbA1c及空腹、餐后血糖均较前明显下降,两组下降幅度比较无统计学意义,但甘精胰岛素注射组低血糖事件明显少于预混胰岛素组。结论老年2型糖尿病患者在单用口服降糖药不能良好控制血糖时,建议给予甘精胰岛素联合口服阿卡波糖,可以良好地控制高血糖,且低血糖发生率低。

Objective To observe the clinical effect and safety on treatment with insulin glargine combined with acarbose for senile typeII diabetes.Methods 60 cases of such patient were divided into two groups.The test group was injected insulin glargine at 22 pm.on basesd acarbose.The control group was injected mixed insulin before breakfast and supper.The course was 16 weeks to observe the empty stomach 7.2 mmol/L and PPBS 10.0 mmol/L as adjust standard.Results The HbAlc,blood sugar level were decrease in both groups P0.05.But the hypoglycemia was lower in test group than that in control group.Conclusion The good suggestion might be insulin glargine combined with acarbose should be better to control blood sugar without hypoglycemia.