4-苯基-3-异恶唑羧酸乙酯的合成

Synthesis of Ethyl 4-Phenylisoxazol-3-Carboxylate

以苯乙腈为原料,通过与草酸二乙酯的缩合反应,与盐酸羟胺的环化反应以及重氮化脱氨基反应,合成4-苯基-3-异恶唑羧酸乙酯。通过对关键步骤重氮化脱氨基的反应条件的优化,产物总收率达到70%。

Ethyl 4-phenylisoxazol-3-carboxylate was synthesized by condensation of benzeneacetonitrile and ethyl oxalate,cyclization with hydroxyamine,and deamination by diazotization reaction in an overall yield of 70%.