奥曲肽联合小剂量垂体后叶素治疗肝硬化上消化道出血的疗效观察

The Effect Observation of Octreotide Combined with Low Dose Pituitrin in Treatment of Hepatic Cirrhosis Upper Gastrointestinal Bleeding

目的探讨奥曲肽、垂体后叶素联合治疗肝硬化并上消化道出血的临床疗效。方法对108例确诊的肝硬化并上消化道出血的患者随机分为两组,A组(60例)奥曲肽联合小剂量垂体后叶素组;B组(48例)奥曲肽组。各组均给予相同的禁食、留置胃管、口服去甲肾上腺素及输血、补液等支持治疗。用药后定期抽取胃内容物观察胃内出血变化情况。结果两组治疗中止血显效率分别为33.3%、16.7%,总有效率分别为95.0%、83.3%。两组不良反应发生率分别为6.67%、6.25%。结论奥曲肽联合小剂量垂体后叶素治疗肝硬化并上消化道出血止血迅速,效果显著,具有较好的临床疗效,且副作用较小。

Objective To investigate the effect of Octreotide combined with low dose Pituitrin in treatment of hepatic cirrhosis upper gastrointestinal bleeding.Methods 108 patients with hepatic cirrhosis upper gastrointestinal bleeding were divided into two groups randomly.Group A（n=60） was treated with Octreotide combined with low dose Pituitrin;Group B（n=48） was treated with single Octreotide.Every group was given the same treatment as ambrosia,detaining the canal of stomach,oral using the norepinephrine,blood-transfusion,fluid replacement and so on.The gastric contents were drawn to observe bleeding condition regularly.Results The control excellence rates of bleeding were 33.3% and 16.7% respectively.The total effective rate were 95.0% and 83.3% respectively.The adverse reaction rate were 6.67% and 6.25% respectively.Conclusion Octreotide combined with low dose Pituitrin stops bleeding quickly in treatment of hepatic cirrhosis upper gastrointestinal bleeding.It has significant clinical effect and less side effect.