斑蝥酸钠维生素B_6注射液联合化疗治疗晚期肺癌

Treatment of Advanced Lung Cancer with Sodium Cantharidinate and Vitamin B_6 Injection in Combination with Chemotherapy

目的:评价斑蝥酸钠维生素B_6注射液联合化疗治疗晚期非小细胞肺癌的临床疗效及不良反应。方法:将68例晚期非小细胞肺癌患者随机分为两组,治疗组(35例)给予斑蝥酸钠维生素B_6注射液25 ml,同时进行多西紫杉醇联合奈达铂化疗,对照组(33例)予单纯联合化疗。治疗2周期后评价两组的疗效、毒副反应及生活质量改变。结果:治疗组、对照组的有效率分别为54.29%和24.27%(P<0.05)。治疗组患者生活质量提高率高于对照组(P<0.05),毒性反应小于对照组(P<0.05)。结论:斑蝥酸钠维生素B_6注射液联合化疗治疗晚期非小细胞肺癌可提高临床疗效,改善患者的生活质量,同时可减少化疗毒副反应。

Objective ： To observe the clinical therapeutic effect and toxic reaction of sodium cantharidinate and vitamin B6 injection on the treatment of advanced lung cancer. Method ：68 advanced non-small cell lung cancer patients were randomly divided into a treatment group （35 cases） and a controlled group （33 cases）. The treatment group accepted chemotherapy in combination with sodium cantharidinate and vitamin B6 therapy. The controlled group accepted chemotherapy only. The clinical therapeutic effect, toxic reaction and life quality were compared between the two groups after two cycles of chemotherapy. Result：The effective rate of the treatment group and controlled group were 54.29% and 24.27% respectively （P 〈 0.05）. The improvement rate of life quality of the treatment group was higher than that of the controlled group （ P 〈 0.05 ）. The toxic reaction of the treatment group was lower than that of the controlled group （ P 〈 0.05 ）. Conclusion：Sodium cantharidinate and vitamin B6 injection combined with chemotherapy had a good effect on advanced nonsmall cell lung cancer patients and could improve the quality of life and reduce drug adverse reaction.