武汉地区33家医院2008～2010年5-HT_3受体拮抗药应用分析

Analysis of 5-HT_3 Receptor Antagonists in Wuhan Area during the Period 2008-2010

目的:研究5-HT_3受体拮抗药在武汉地区的应用情况和发展趋势。方法:采用世界卫生组织推荐的限定日剂量为指标的分析方法,对武汉地区33家医院2008～2010年5-HT_3受体拮抗药有关数据进行统计分析。结果:5-HT_3受体拮抗药销售金额逐年增加,托烷司琼使用频度的构成比最高,帕洛诺司琼的销售金额与使用频度增长迅速。结论:第一代5-HT_3受体拮抗药仍然是化疗呕吐治疗的一线用药,第二代5-HT_3受体拮抗药在治疗化疗呕吐领域越来越受到重视。

Objective： To evaluate the current situation and the developing trend of 5-HT3 receptor＇antagonists used in 33 hospital of Wuhan during the period of 2008-2010. Method ：The 5-HT3 receptor antagonists were statistically analyzed in respect to consumption sum, DDDs and daily costs. Result：During the 3 years, consumption sum of 5-HT3 receptor antagonists were yearly increasing. Tropisetron ranked the first in constituent ratios of consumption sum. The market of palonosetron showed a rapid increasing tendency. Conclusion：The first generation 5-HT3 receptor antagonists are the firstchoice drugs in the clinic, while the second generation 5-HT3 receptor antagonists will be gradually accepted by doctors.