奥美拉唑不良反应文献分析

Literature Analysis of Omeprazole-induced Adverse Drug Reactions

目的:探讨奥美拉唑不良反应发生的规律及特点,为临床合理用药提供参考。方法:通过中国知网(CNKI)的中国医院知识仓库(CHKD)期刊全文数据库及万方数据库检索到2000～2010年有关奥美拉唑致不良反应的有效文献,并按患者性别、年龄、原患疾病与过敏史、给药途径、累及器官或系统及临床表现等方面进行统计、分析。结果:收集奥美拉唑所致不良反应50例,其中,不良反应以过敏性反应和血液系统反应最多。结论:奥美拉唑引起的不良反应临床表现复杂多样,其发生与多种因素有关,值得临床医师关注。

Objective：To explore the regularity and characteristics of ADRs induced by omeprazole. Method： Based on the CHKD and Wanfang database,literatures about omeprazoleinduced ADRs from 2000 to 2010 were collected and statistically afialyzed in respect of patients＇ gender, age, case history, administration route, clinical manifestation. Result ：The most ADRs were anaphylactic reactions and hematological system damage. Conelnsion： ADRs induced by omeprazole presented complicated and various symptoms owing to different reasons. Clinical doctors should pay more attention to the omeprazole-induced ADRs.