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阿尔采末病APP分泌酶及其靶向干预研究进展 被引量：5

Progress of APP secretase and targeted intervention on Alzheimer's disease
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摘要 α、β和γ3种分泌酶是淀粉样前体蛋白(APP)加工及代谢的关键酶,选择性地激活α分泌酶或抑制β和γ分泌酶,将有助于减少β-淀粉样蛋白(Aβ)的产生,并可能成为治疗AD的有效靶点。该文主要对APP 3种分泌酶活性表达的影响因素及其靶向干预研究的进展做一综述。 α,β and γ secretases are three kinds of key enzymes in processing and metabolizing amyloid precursor protein（APP）.Their selective activation of the α secretase or inhibition of β and γ secretase will help reduce the production of β-amyloid protein（Aβ）,and may become one of the effective targets to treating AD.This paper aims to make a review on the research development of relevant factors influencing the activity and expression of 3 APP secretases and their targeted intervention in pharmaceutical studies.
作者 李守业 朱妍 焦悦 李昌煜
机构地区 浙江中医药大学
出处 《中国药理学通报》 CAS CSCD 北大核心 2011年第10期1349-1353,共5页 Chinese Pharmacological Bulletin
基金 浙江省科技计划资助项目(No2007C23021) 浙江省研究生创新科研资助项目(No71015111) 浙江省新苗人才计划资助项目(No2010R410016)
关键词 阿尔采末病 Β-淀粉样前体蛋白 分泌酶 靶向干预 激动剂 抑制剂 机制 Alzheimer＇s disease amyloid precursor protein secretase targeted intervention agonist inhibitor mechanism
分类号 R-05 [医药卫生] R341 [医药卫生—基础医学]
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参考文献16

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共引文献26

同被引文献55

  • 1赖菲菲,孙治中,黄勇智,胡小英.基于网络药理学探讨麻黄治疗儿童哮喘作用机制[J].辽宁中医药大学学报,2019,0(11):211-217. 被引量：20
  • 2邱宇,黄玲.钙离子通道对支气管哮喘影响的研究进展[J].中华哮喘杂志（电子版）,2013,7(2):131-134. 被引量：7
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引证文献5

二级引证文献8

中国药理学通报
2011年 第10期

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