5%咪喹莫特乳膏每日1次治疗尖锐湿疣68例

Effects of 5% imiquimod cream once a day in 68 patients with condyloma acuminatum

目的观察5%咪喹莫特乳膏每日一次治疗尖锐湿疣的疗效。方法尖锐湿疣患者98例,分为2组。试验组68例,每日患处直接外用足量5%咪喹莫特乳膏一次,共4 wk。对照组30例,隔日患处直接外用足量5%咪喹莫特乳膏一次,共8 wk。观察治疗前后疣体发生的部位、数目、形状、大小及用药后局部刺激和全身不良反应。结果试验组退出1例,治疗4 wk后有效率为69%(46/67),对照组治疗8 wk后有效率为73%(22/30),2组疗效无显著差异(P>0.05)。试验组疣体消退时间为(12.5±6.5)d,对照组为(40.5±12.2)d,试验组短于对照组,差异有显著意义(P<0.05)。试验组不良反应发生率为50%,对照组为40%,无显著差异(P>0.05)。结论 5%咪喹莫特乳膏每日一次治疗尖锐湿疣疗效与隔日一次相当,可缩短疗程。

AIM To study the effects of 5% imiqfiimod cream once a day on condyloma acuminatum. METHODS A total of 98 patients with condyloma acuminatum were assigned to trial group （n = 68） and control group （n = 30）, and were respectively administered with 5% imiquimod cream once a day for 4 wk and 5% imiquimod cream once two days for 8 wk. Anatomic site of the wart, wart number, wart morphology, wart size and adverse reactions were observed. RESULTS The effective rates of the trial group and the control group were 69% （46/67） and 73% （22/30） at the end of the treatment, respectively. There was no significant difference in clinical effect between two groups （P 〉 0.05） . Wart regression time of the trial group was （12.5 ± 6.5）d, shorter than that of the control group （（40.5 ± 12.2）d, P 〈 0.05）. There was no significant difference in the incidence of local adverse reactions （50% in the trial group and 40% in the control group, P 〉 0.05）. No serious adverse reactions occurred. CONCLUSION In the treatment of condyloma acuminatum, 5% imiquimod cream once a day is effective as 5% imiquimod cream once two days, and can shorten the course of treatment.