大鼠模拟晕船适应过程中体内铁、锌含量的变化

Changes in the contents of Fe and Zu in the body of simulated seasickness adaptation rats

目的 观察大鼠模拟晕船适应过程中血浆、脑、肾和肝中铁锌的变化。方法 动物通过模拟晕船刺激，利用异食癖观察动物晕船表现，筛选出晕船易感大鼠36只，再按数字表法随机分为对照组（n=12）与模拟晕船组（n=24），模拟晕船组大鼠用模拟晕船装置变速刺激3 h/d，分别于模拟晕船刺激后第1、3、7、21天断头处死，取血浆和内脏，采用原子吸收火焰法检测铁锌的含量。结果 血浆和脑中铁含量晕船发生后均下降，尤其是晕船刺激第1天显著低于对照组，脑中锌含量在晕船刺激第1天明显低于对照组。结论 晕船刚开始时大鼠血浆中铁及脑中铁锌含量显著降低。

Objective To observe changes in the contents of Fe and Zn in the brain, liver, kidney and plasma in rats with simulated seasickness. Methods A seasickness simulator was used to induce seasickness and pica was used as an indicator. The rats were then randomly divided into 2 groups： the normal control group （n = 12） and the simulated seasickness group （n = 24）. The rats in the seasickness group received angular acceleration for 3 h/d in the simulator. Then, the 24 rats were sacrificed in 4 batches on day 1, 3, 7 and 21 respectively, following simulated seasickness. Contents of Fe and Zn in the brain, liver, kidney and plasma were measured with Flame Atomic Absorption Spectrometry. Results When compared with those of the control group, contents of Fe in the brain and plasma all decreased following onset of seasickness, with more significant decrease in the content of Fe on day 1 in particular, following simulated seasickness. The contents of Zn in brain were also significantly lower than those of the control group, following seasickness simulation on day 1. Conclusions The contents of Fe in plasma, the contents of Fe and Zn in brain decreased significantly at the onset of seasickness.