雷莫司琼和托烷司琼预防口腔颌面外科术后恶心、呕吐的疗效观察

Clinical observation of ramosetron and tropisetron in prevention postoperative nausea and vomiting after oral and maxillofacial surgery

目的:比较雷莫司琼和托烷司琼预防口腔颌面外科术后恶心、呕吐的效果。方法:选择120例ASAⅠ～Ⅱ级择期行口腔颌面外科手术的患者,随机分为3组,在麻醉诱导前静脉注射雷莫司琼(R组,n=40)0.3mg、托烷司琼(T组,n=40)5mg、生理盐水(对照组,C组,n=40)5mL。观察术后24h内恶心、呕吐的发生情况,采用SPSS 11.0软件包对数据进行χ2检验。结果:术后24h内,恶心、呕吐的发生率R组和T组显著低于C组,差异有统计学意义(P<0.05),R组和T组比较差异无统计学意义(P>0.05)。结论:雷莫司琼和托烷司琼均可显著减少术后恶心、呕吐的发生率,两者疗效相当。

PURPOSE： To compare the preventive of ramosetron and tropisetron on postoperative nausea and vomiting after oral and maxillofacial surgery.METHODS： One hundred and twenty ASA Ⅰ-Ⅱgrade patients undergoing selective oral and maxillofacial surgery were randomly divided into 3 groups.0.3mg ramosetron（group R,n=40）,5mg tropisetron（group T,n=40） and 5mL normal saline（control group,group C,n=40） were intravenously given to the patients respectively at the begin of general anesthesia.The patients were observed within 24h after operation for nausea and vomiting.The percentage of occurrence was compared with SPSS11.0 software package for χ2 test.RESULTS： After 24 hours,the incidence of nausea and vomiting in group R and group T was significantly lower than group C（P0.05）,but no difference existed between group R and group T（P0.05）.CONCLUSION： Ramosetron and tropisetron can significantly reduce the incidence of postoperative nausea and vomiting,and there is no difference in prevention of nausea and vomiting between the two drugs.