期刊文献+

结缔组织生长因子在肝细胞上皮-间充质转分化及肝纤维化形成中的作用研究进展 被引量:2

The role of CTGF in mediating hepatocytes epithelial-tomesenchymal transition and hepatic fibrogenesis
原文传递
导出
摘要 纤维化是器官(肝、肾、肺等)慢性功能衰竭的一个共同机制,目前尚无有效防治方法。对上皮-间充质转分化(epithelial—to—mesenchymaltransition,EMT)的研究使人们对器官纤维化的传统认识受到挑战,逆转分化已被认为是未来抗肝纤维化治疗的重要策略之一。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2011年第10期795-797,共3页 Chinese Journal of Hepatology
基金 中国肝炎基金会王宝恩肝纤维化研究基金(20090007) 国家自然科学基金(81070344)
关键词 肝硬化 结缔组织生长因子 上皮-间质转 分化 Liver cirrhosis Connective tissure growth factor Epithelial-to-mesenchymal transition
  • 相关文献

参考文献21

  • 1Choi SS, Diehl AM. Epithelial-to-mesenchymal transitions in the liver. Hepatology, 2009, 50: 2007-2013.
  • 2Zeisberg M, Yang C, Martino M, et al. Fibroblasts derive from hepatocytes in fiver fibrosis via epithelial to mesenchymal transition. J Biol Chern, 2007, 282: 23337-23347.
  • 3Meindl-Beinker NM, Dooley S. Transforming growth factor-beta and hepatocyte transdifferenliation in liver fibrogenesis. J Gastroenterol Hepatol, 2008,23 Suppl 1: S122-127.
  • 4Gressner OA, Gressner AM. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int,2008, 28: 1065-1079.
  • 5Gressner OA, Lahrne B, Siluschek M, et al. Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes--but without modulating bone morphogenetic protein 7 signaling. Hepatology, 2009, 49: 2021-2030.
  • 6Friedman SL. Mechanisms of hepatic fibrogenesis. Craslroenterology, 2008, 134: 1655-1669.
  • 7Higashiyama R, Moro T, Nakao S, et al. Negligible contribution of bone marrow-derived ceils to collagen production during hepatic fibrogenesis in mice. Gastroenterology, 2009, 137: 1459-1466.
  • 8Syn WK, Jung Y, Omenetti A, et al. Hedgehog-mediated epithelial-to- mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology, 2009,137: 1478-1488.
  • 9Dooley S, Hamzavi J, Ciuclan L, et al. Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against fiver damage. Gastroenterology, 2008, 135: 642-659.
  • 10Tong Z, Chen R, Alt DS, et al. Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatoeytes. Hepatology, 2009, 50: 939-947.

同被引文献19

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部