急性脑梗死患者血糖、肌酐、尿素氮及血清ET-1水平的研究

Study on glucose, creatinine, urea nitrogen and serum ET-1 of patients with acute cerebral

目的探讨急性脑梗死患者血糖、肌酐、尿素氮及血清内皮素（endothelin-l，ET-1）水平的变化及其神经功能缺损程度与ET-1水平的关系。方法用^1 2 5I放射免疫法分析50例发病在24h内的急性脑梗死患者与对照组50例同期非神经系统疾病患者血清ET-1水平的变化，并比较其血糖、肌酐及尿素氮水平。结果急性脑梗死组血糖、肌酐及尿素氮水平差异无统计学意义（P〉0．05），但血清ET．1水平显著性高于对照组（P〈0．01），且急性脑梗死血清ET-1水平的变化与其神经功能缺损程度显著性相关，不同组问均P值〈0．01。结论血清ET-1水平可作为急性脑梗死发生预测及预后评估的指标之一。

Objective To study glucose, creatinine, urea nitrogen and serum ET-1 of patients withacute cerebral infarction, and to explore the relationship between neurologic impairment and ET-1 levels. Methods The glucose, creatinine, urea nitrogen and serum ET-1 were retrospectively analyzed in 50 patients with acute cerebral infarction （ 〈 24 h） and 50 patients with non-neurological diseases. ET-1 determined by 125I radioimmunoassay. Results There were no significant differences in glucose, creatinine and urea nitrogen of acute cerebral infarction （ P 〉 0. 05 ） ; Compared to the control groups, ET-1 levels was significantly higher （ P 〈 0. 01 ）, and levels of serum ET-1 in acute cerebral infarction were significantly correlated with their neurological deficits （P 〈 0. 01 ）. Conclusions Levels of serum ET-1 can severd as diagnostic and prognostic indicator of acute cerebral infarction.