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ABO血型不合对HLA相合异基因外周血干细胞移植的影响 被引量:1

The effects of ABO incompatible on HLA matched allogeneic peripheral blood stem cell transplantation
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摘要 目的在非血缘移植比例增加、移植物抗宿主病(GVHD)发生率增加、免疫抑制剂用量加大的情况下,分析ABO血型不合对HLA相合异基因外周血干细胞移植(allo-BPSCT)的影响。方法将43例ABO血型不合的allo-PBSCT患者与同期49例ABO血型相合的受者进行比较。结果 ABO血型不合组与相合组输注红细胞量分别为(7.73±7.61)u和(4.33±3.24)u(P=0.040),ABO血型不合组与相合组血红蛋白恢复到100g/L的时间分别为(54.08±45.24)d和(32.46±16.95)d(P=0.009)。ABO血型不合组较相合组红细胞输注量多,红系恢复时间长。两组间移植相关并发症差异无统计学意义。结论 ABO血型不合不影响造血干细胞移植的植活、主要合并症及预后。ABO血型不合组较相合组红细胞输注量多,红系恢复较慢。 Objective In the case of un-related transplant proportion,GVHD incidence and the amount of immunosuppressive drugs increased,We analyze the effects of ABO incompatibility on HLA matched allogeneic peripheral blood stem cell transplantation(allo-BPSCT).Methods We compared 43 cases of ABO incompatibility patients with the same period 49 cases of ABO-matched patients who have been carried out allo-PBSCT in our hospital.Results ABO incompatibility group patients need more red blood cell transfusions,and red blood cells need longer recovery time than in the matched group patients.The differences of transplant-related complications between the two groups were not statistically significant.Conclusion ABO incompatibility does not affect the hematopoietic stem cell transplantation engraftment,the main complications and prognosis.ABO-incompatible group need more red blood cell transfusion than matched group,erythroid recovery slower.
出处 《热带医学杂志》 CAS 2011年第9期1007-1010,共4页 Journal of Tropical Medicine
关键词 造血干细胞移植 血型不合 ABO血型系统 hematopoietic stem cell transplantation blood group incompatibility ABO blood group system
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