TEA方案治疗复发/难治急性髓性白血病的临床研究

Clinical study of TEA regimen in the treatment of relapsed/refractory acute myeloid leukemia

目的：研究吡喃阿霉素（THP）、足叶已甙及阿糖胞苷联合应用（TEA方案）治疗复发/难治急性髓性白血病的疗效和不良反应。方法：THP20mg/d,静滴3d,足叶已甙100mg/d,静滴3d,阿糖胞苷100mg/d,静滴5~7d,为1疗程。共治疗15例复发/难治急性髓性白血病患者。结果：5例达完全缓解（CR）,CR率33.3%,3例达部分缓解（PR）,PR率20%,总有效率53.3%,5例未缓解（NR）,2例因自动出院无法判断。毒副作用包括骨髓抑制、发热、胃肠道反应和轻度肝损伤。结论：TEA方案治疗复发/难治急性髓性白血病疗效好,副作用少,值得推广应用。

Objective：To study the efficacy and side effects of combined pirarubicin（THP）,etoposide,and cytarabine（TEA regimen） in the treatment of relapsed/refractory acute myeloid leukemia.Methods：A course of treatment included 20mg/d of THP with intravenous infusion for 3 d,100mg/d of etoposide with intravenous infusion for 3 d,and 100mg/d of cytarabine with intravenous infusion for 5~7 d.Fifteen eligible patients diagnosed as relapsed/refractory acute myeloid leukemia were enrolled and received the TEA regimen in this study.Results：Five cases achieved complete remission（CR）,with a CR rate of 33.3%,while 3 cases reached partial remission（PR）,with a PR rate of 20%,resulting in a total efficacy rate of 53.3%.Five patients ended up with non-remission（NR） while 2 cases were discharged earlier and could not be followed-up.Side effects included bone marrow suppression,fever,gastrointestinal disorders and mild liver injury.Conclusion：TEA regimen in the treatment of relapsed/refractory acute myeloid leukemia is effective,showed mild side effects,and should be widely promoted.