新生儿败血症患儿治疗前后血清IL-2、IL-6和GM-CSF检测的临床意义

Clinical Significance of Determination of Serum IL-2,IL-6 and GM-CSF Levels After Treatment in Pediatric Patients with Neonatal Septicemia

目的:探索了新生儿败血症患儿治疗前后血清IL-2I、L-6和GM-CSF含量的变化及临床意义。方法:应用放射免疫分析对31例新生儿败血症患儿进行了治疗前后血清IL-2I、L-6和GM-CSF测定,并与30名正常健康儿作比较。结果:在治疗前血清IL-6和GM-CSF水平显著高于正常新生儿组(P<0.01),而IL-2水平又非常显著地低于正常新生儿组(P<0.01),经治疗1个月后则与正常儿比较无显著性差异(P>0.05)。相关分析显示,血清IL-2水平与IL-6、GM-CSF水平呈显著负相关(r=-0.4108、-0.5187,P<0.01)。结论:血清IL-2I、L-6和GM-CSF在新生儿败血症的发生、发展过程中相互作用,观察其浓度的变化对探讨其发病机理及指导用药均具有重要的临床价值。

Objective To explore the clinical significance of changes of serum IL-2,IL-6 and GM-CSF levels after treatment in pediatric patients with newborn septicemia. Methods Serum levels of IL-2,IL-6 and GM-CSF levels were measured with RIA in 31 pediatric patients with newborn septicemia and 30 normal healthy controls.Results Before treatment,the serum levels of IL-6 and GM-CSF levels were significantly higher in the patients than those in controls（P0.01）,but serum IL-2 levels were obviously lower in the patients（P0.01）.After treatment for 1 mon,the serum IL-2,IL-6 and GM-CSF levels were not significantly different from those in controls（P0.05）.Conclusion These cytokines participated in the pathogenesis of newborn septicemia in pediatric patients.Mornitoring the changes of their serum levels were helpful for the management of the diseases.