支气管肺炎患儿治疗前后血清IGF-Ⅱ、IL-2和SOD检测的临床意义

Clinical Significance of Changes of Serum IGF-Ⅱ,IL-2 and SOD Levels After Treatment in Pediatric Patients with Bronchial Pneumonia

目的:探讨支气管肺炎患儿治疗前后血清IGF-Ⅱ、IL-2和SOD水平的变化及临床意义。方法:应用放射免疫分析对33例支气管肺炎患者进行治疗前后血清IGF-Ⅱ、IL-2和SOD检测,并与35名正常儿作比较。结果:在治疗前支气管肺炎患儿血清IGF-Ⅱ水平非常显著地高于正常儿组(P<0.01),而血清IL-2、SOD水平则极显著地低于正常儿组(P<0.01)。经综合治疗2周后即与正常儿组比较无显著性差异(P>0.05)。结论:检测支气管肺炎患儿治疗前后血清IGF-Ⅱ、IL-2和SOD水平的变化对了解病情、观察预后均具有一定的临床价值。

Objective To investigate the clinical significance of changes of serum IGF-Ⅱ,IL-2 and SOD levels after treatment in pediatric patients with bronchial pneumonia. Methods Serum IGF-Ⅱ,IL-2 and SOD（with RIA） levels were measured in 33 pediatric patients with bronchial pneumonia both before and after treatment as well as in 35 controls.Results Before treatment,serum IGF-Ⅱ levels in the patients were significantly higher than those in controls（P0.01）,while the serum IL-2,SOD levels were prominently lower than those in controls（P0.01）.Two weeks after treatment the levels were no more difference from those in controls（P0.05）.Conclusion Changes of serum IGF-Ⅱ,IL-2 and SOD levels both beforeand after treatment could reflect the diseases status of the patients as well as the progress of diseases,and might be of prognostic importance in pediatric patients with bronchial pneumonia.