应用抗抑郁药配合常规治疗冠心病患者临床疗效的探讨

Study of clinical efficacy of the application of combining antidepressants and conventional treatment of patients with coronary disease

目的探讨抗抑郁药的应用对冠心病患者临床疗效的影响。方法对筛选出的60例冠心病合并抑郁情绪的患者按随机原则分为两组,实验组和对照组各30例。实验组进行冠心病常规药物治疗的同时加用抗抑郁药,对照组只进行常规药物治疗,两组分别于治疗前、治疗8周后各进行一次心电图检查和抑郁自评量表(SDS)测定,两组于治疗4周后再行一次SDS的测定,将所有的检查、测定结果列表进行比较。结果实验组心电图症状的改变、SDS的评分改变与对照组比较差异有统计学意义(P<0.05或0.01)。结论抗抑郁药配合常规治疗冠心病的疗效显著,值得在临床冠心病治疗中推广应用。

Objective To investigate the efficacy of the application of antidepressants on patients with coronary disease.Methods 60 patients with coronary disease concurrent with depression were selected.According to statistics,they were randomly divided into two groups：the experimental group and the control group,with 30 members in each group.The experimental group was treated with conventional coronary disease therapy plus antidepressants,while the control group was treated only with conventional therapy.Each group had electrocardiographic examination and SDS tests before treatment and after 8 weeks of the experiment they had examinations and tests again.SDS tests were also conducted after 4 weeks of the treatment.All the results were collected in the end for comparing. Results There was statistical difference in ECG changes and SDS scores of the experimental group and the control group（P0.05 or 0.01）. Conclusion Antidepressants can enhance the effects of conventional coronary disease treatment.Such therapy is worth popularizing in the clinical treatment of coronary heart disease.