相转移催化合成对溴苯甲酸的研究

The Synthesis of 4-Bromobenzoic Acid with Phase Transfer Catalyst

研究了以水为溶剂,三乙基苄基氯化胺(TEBA)为催化剂,对溴甲苯为原料,高锰酸钾为氧化剂,在酸性和碱性条件下合成对溴苯甲酸的反应.考察了催化剂用量、反应物摩尔比、反应温度、反应时间等对反应的影响.最优条件为:以水为溶剂,n(对溴甲苯)∶n(KMnO4)∶n(Na2CO3)为1.0∶2.5∶1.0,TEBA(5%)为催化剂,反应温度95℃,反应时间2.5 h,对溴苯甲酸的产率可达82.44%.

Research on synthesis of 4-bromobenzoic acid was investigated with 4-bromotoluene as raw material,potassium permanganate as the oxidant,TEBA as catalyst,in acid or alkali conditions.A series of experiments were inspected to study the influence on the reaction.Optimization： with water as solvent,TEBA（5%） as catalyst,n（4-bromotoluene）∶n（KMnO4）∶n（Na2CO3）=1.0∶2.5∶1.0,at 95℃ for 2.5 h,4-bromobenzoic acid was obtained in the yield of 82.4%.