恙虫病患者检测三种细胞因子的临床意义

The clinical value of determination three cytokine levels in scrub typhus patients

目的探讨恙虫病患者检测血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、粒细胞集落刺激因子(G-CSF)的临床意义。方法采用ELISA方法检测恙虫病51例(观察组)治疗前后血清IL-6、TNF-α、G-CSF的浓度,并与健康体检者(对照组)比较分析。结果与对照组比较,观察组治疗前IL-6、TNF-α、G-CSF均明显升高,差异有统计学意义(P<0.05);观察组治疗2周后此3项细胞因子水平明显降低,差异有统计学意义(P<0.05)。结论检测IL-6、TNF-α、G-CSF对恙虫病患者的诊断及治疗有重要的临床意义。

Objective To explore the clinical value of determination IL-6,TNF-α and G-CSF level in scrub typhus patients.Methods The concentrations of IL-6,TNF-α and G-CSF were measured by using an enzyme-linked immunoassay in 51 patients with scrub typhus（experimental group）and in 51 health cases（control group）.IL-6,TNF-α and G-CSF were compared between control and experimental groups.2 weeks after therapy in experimental group,the three cytokine were detected again.Results The levels of IL-6,TNF-α and G-CSF in the scrub typhus group increased obviously compared to the control group（P〈0.05）,and these cytokine levels were significant lower 2 weeks after therapy in experimental group（P〈0.05）.Conclusion The determination of IL-6,TNF-α and G-CSF in scrub typhus patients has important clinical value.