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氯吡格雷与质子泵抑制剂相互作用的研究进展 被引量:2

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摘要 急性冠状动脉综合征患者被推荐服用氯吡格雷时合用质子泵抑制剂(PPIs),以降低患者胃肠道出血的发生率。近年来有些学者关注氯吡格雷与PPIs之间的相互作用,众多研究的结论也是矛盾的,因此给服用氯吡格雷的患者开PPIs处方之前,强化消化道出血风险及心血管风险的个体化危险评估仍是非常必要的。
出处 《东南国防医药》 2011年第5期440-443,共4页 Military Medical Journal of Southeast China
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  • 1Yusuf S,Zhoa F,Mehla SR,etal.Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST segment elevation[J].N Engl J Med,2001,345(7):494-502.
  • 2Nikolsky E,Stone GW.Kirtane AJ,et al.Gastrointesdnal bleeding in patients with acute coronary syndromes:incidence,predictors,and clinical implications:analysis from the ACUITY (Acute Catb eterization and Urgent Intervention Triage Strategy) Trial[J].J Am Coil Cardiol,2009,54(14):1293-1302.
  • 3Bhatt DL,ScheimanJ,Abraham NS,et al.ACCF/ACG/AHA 2O08 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSA1D use:a report of the American Col lege of Cardiology Foundation Task Force on Clinical Expert Con sensus Documents[J].J Am Coll Cardiol,2008,52(18):1502-1517.
  • 4Cilard M,Arnaud B,Comily JC,et al.Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin:the randomized double-blind OCLA (Omepnzole CLopidogrel Aspi rin) study[J].J Am Coll Caidiol,2008,51(3):256-260.
  • 5Hulot JS.Bura A.Villard E,et al Cytochrome P45O 2C19 loss-of function polymorphiam is a major determinant of clopidogrel re sponsiveneas in healthy subjecto[J].Blood,2006,108(7):2244-2247.
  • 6Blume H.Donath F.Warnke A,et al.Phannacokinetic drug inter action profiles of proton pump inhibitors[J].Drug Saf,2006,29 (9):769-784.
  • 7Coutls RT.Unchuk LJ.Polymorphic cytochromes p450 and drugs used in psychiatry[J].Cell,1999,19(3):325-354.
  • 8Desta Z,Zhao X,Shin JG,Flockhart DA.Clinical significance of the cytochrome P450 2C19 genetic polymorphism[J].Clin Phar macokinet,2002,41(12):913-958.
  • 9Fontana P,Hulot JS.De Moerloose P,et al.Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects[J].J Thromb Haemost,2007,5 (10):2153-2155.
  • 10Simon T.Verstuyft C,Mary-Krause M,et al.Genetic determinants of response to clopidogrel and cardiovascular events[J].N Engl J Med,2009,360(4):363-375.

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