氟比洛芬酯术前预处理对患者术中应激反应的影响

Effects of Preoperative Pretreatment of Flurbiprofen on Stress Response of Patients in the Surgery

目的:探讨氟比洛芬酯术前预处理对患者术中应激反应的影响。方法:选择我院行全麻下腹式子宫全切术患者60例,随机分为观察组和对照组,每组30例。两组均采用相同的麻醉诱导和维持方案,观察组于手术开始前10min缓慢静注氟比洛芬酯脂微球注射液1mg.Kg。记录诱导前、切皮时、探查时和术毕的平均动脉压和心率;放射免疫分析法测定患者血浆中血浆肾素、血管紧张素II、醛固酮、皮质醇的浓度变化。结果:观察组心率、平均动脉压在切皮时、探查时、术毕时均较对照组低,但无显著性差异(P>0.05);观察组切皮时、探查时、术毕时血浆肾素、血管紧张素II、醛固酮、皮质醇浓度均较对照组低,且差异具有统计学意义(P<0.05);两组术中的四种麻药用量均有不同,但差异无统计学意义(P>0.05)。结论:氟比洛芬酯术前预处理能降低腹式子宫全切术中机体的应激反应,值得推广应用。

Objective： To study the effect of preoperative pretreamaent of flurbiprofen to the patients with stress response in the surgery. Methods： 60 patients undergoing abdominal hysterectomy were randomly divided into observation group and control group and 30 cases were in each group. Both of groups were given the same anesthetic induction and maintenance programs, and observation group was slowly injected lmg/Kg of flurbiprofen by intravenous. Recorded the average arterial pressure and heart rate before induction, at skin incision, exploration and the completion of surgery and determined the changes of concentration of plasma renin, angiotensin II, aldosterone and cortisol. Results： The average arterial pressure and the heart rate in the observation group were higher than that in the control group at the time of incision, probe and surgery, however, there was no significant difference between the two groups （P〉0.05）; the concentration of plasma renin, angiotensin II, aldosterone and cortisol in the observation group were lower than that in the control group and the difference was statistically significant （P〈0.05）; the consumption of four anesthetic drugs in the two groups were different, however, the difference was not statistically significant （P〉0.05）. Conclusion： Preop6rative pretreatment of flurbiprofen can reduce the body＇s stress response of abdominal hysterectomy, which should be widely applied.