P-gp、MRP1、GST-π与新疆维吾尔族宫颈癌新辅助化疗疗效的相关性研究

Relationship Among the Expression of P-Glycoprotein,Multiple Resistance-Associated Protein-1,and GST-π in Cervical Squmous Cancer for Prediction of Response to Neoadjuvant Chemotherapy in Uigur Women

目的:探讨新疆维吾尔族宫颈癌新辅助化疗前后P-gp、MRPI和GST-π的表达及其与化疗疗效的关系。方法:运用S-P法分别检测维吾尔族妇女宫颈鳞癌组织22例新辅助化疗前后及正常宫颈组织20例P-gP、MRPI和GST-π的表达水平。结果:①新疆维吾尔族正常宫颈、初治宫颈癌组织中P-gp的阳性表达率分别为10%、40.9%;MRP1的阳性表达率分别为15%、31.8%;GST-π的阳性表达率分别为45%、9.01%。P-gp和GST-π在各组间比较差异均有统计学意义(P<0.05)MRP1差异无统计学意义(P>0.05)。②NACT后宫颈癌组织中P-pg阳性表达显著上升(P<0.05),有统计学意义。NACT后宫颈癌组织中MRP1、GST-π阳性表达上升但差异无统计学意义(P>0.05)。③新疆维吾尔族妇女新辅助化疗前宫颈鳞癌组织中P-gp、MRP1及GST-π表达阴性和阳性患者NACT有效率无显著性差异(P>0.05)。结论:P-pg、MRP1、GST-π无法作为化疗敏感性指标预测维吾尔族宫颈鳞癌新辅助化疗疗效。

Objective： To investigate the Relationship among the expression of P-glycoprotein,Multiple Resistance-associated Protein-l,and GST-П in Cervical Squmous Cancer for Prediction of Response to Neoadjuvant Chemotherapy in Uigur woman. Methods： The specimens of 22 cases with cervical squmous Cancer before and after NACT are examined by S-P immunohistochemistry in ethnic Uigur women with 20 cases of normal control. Results： （1）In ethnic Uigur women：P-gp positive expression rate in normal and cervical squmous cancer before NACT are 10% and 40.9%;MRP1 positive expression rate in normal and cervical squrnous cancer before NACT are 15%, 31.8% ; GST-П positive expression rate in normal and cervical squmous cancer before NACT are 45%, 9.01% o The positive expression rate of P-gp and GST-П in cervical squmous cancer before NACT have a significantly higher than in normal cervical （P〈0. 05）.（2）In ethnic Uigur women： P-pg positive expression rate after NACT was a significantly higher than that before NACT（P〈0.05 ）. （3）In ethnic Uigur women： P-gp MRP1 and GST-П expression negative rate before NACT had no higher effcctive rate than the positive groups（P〉0.05 ）. Conclusion： P-glycoprotein,Multiple Resistance-associated Protein-1 and GST-П can not be used as predictive markers of NACT effective in cervical squmous cancer in Uigur and han women.