摘要
目的:研究p27kip1蛋白和增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在星形细胞瘤中的表达与肿瘤病理分级的关系,探讨p27kip1蛋白在星形细胞瘤演变过程中的意义。方法:SP免疫组化法对64例星形细胞瘤的p27kip1蛋白和PCNA表达进行观察。结果:随着病理级别的升高,p27kip1阳性细胞百分率降低,而PCNA则相反,两者的表达成显著负相关。结论:p27kip1表达的缺失可能与星形细胞瘤的发生发展密切相关,PCNA能较客观地反映肿瘤的恶性程度。
Objective： To detect the expression of the p27kip 1＇l and proliferating cell nuclear antigen （PCNA）in human brain astrocytomas and relationship with the pathology grade and discuss the value of p27kip 1 in astrocytoma development. Methods： SP immunohistochemical analysis was used for detection the expression of p27kip 1 and PCNA in 64 astrocytomas. Results： The percents of p27k＊l positive labeling cells decreased along with the growing of pathology grade in human astrocytomas. However, PCNA was on the contrary , a significant negative correlation is observed between the p27kip 1and PCNA. Conclusion： The decreased p27kip 1 protein expression might play an important role in the genesis and development of human brain astrocytomas, immuohistochemical analysis of PCNA might be useful in deciding the grade of malignant of astrocytoma.
出处
《现代生物医学进展》
CAS
2011年第20期3919-3922,共4页
Progress in Modern Biomedicine
基金
黑龙江省普通高等学校青年学术骨干支持计划项目(1155G33)
