B淋巴细胞刺激因子(BLyS)调控相关蛋白的研究进展

Relative Proteins Involved in Regulation of B Lymphocyte Stimulator (BLyS)

B淋巴细胞刺激因子是肿瘤坏死因子超家族的成员之一,它同自身免疫疾病的发生发展密切相关,BLyS过度表达会促使B淋巴细胞增殖并分泌自身抗体。BLyS也是治疗自身免疫疾病的重要靶点。关于BLyS的调控涉及了许多蛋白。本文主要就G-CSF、TGF-β1、IFN-γ、IL-10和Poly(I:C)等对BLyS的调控作用作一综述。

Blymphocyte stimulator, a member of tumor necrosis factor super family, is relative to nosogenesis and progression of autoimmune diseases. Overexpression of BLyS would promote proliferation of B cells and secration of autoantibodies. BLyS is also regarded as an important target of antoimmune diseases. Many proteins are involved in the regulation of BLyS. We now have a summary on several proteins which play roles in regulation of BLyS, such as G-CSF, TGF-β1, IFN-γ , IL-10, Poly（I：C） and so on.