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乙酰胆碱激活的钾离子通道在心肌中的分布特点及其电生理作用 被引量：4

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摘要 乙酰胆碱(Ach)激活的钾离子通道(KAch)是内向整流钾通道家族中的一员,是由Kir3.1和Kir3.4蛋白以2∶2组成的异四聚体。在传导系统和心房肌细胞膜表达丰富,在心室组织中有少量表达,且沿心肌细胞T管分布。通道活性受Ach等配体激活的G蛋白、细胞外Na+、细胞内PH值等调节,Ach激活的钾电流(IKAch)在维持细胞膜静息电位和动作电位3期复极中起重要作用。IKAch的激活促使心肌细胞膜超极化、兴奋性降低、动作电位时程缩短、自律性降低,IKAch不仅与心房颤动等室上性心律失常密切相关,且其基因突变丧失电生理特性是长QT综合征的病因之一,是心律失常治疗的潜在靶点。
作者 袁章利 张树龙
机构地区 大连医科大学附属第一医院心内科
出处 《中国心脏起搏与心电生理杂志》 北大核心 2011年第5期437-441,共5页 Chinese Journal of Cardiac Pacing and Electrophysiology
关键词 心血管病学 乙酰胆碱激活的钾离子通道 综述 G蛋白 兴奋性 自律性 心律失常
分类号 R541.7 [医药卫生—心血管疾病] R331.38 [医药卫生—人体生理学]
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参考文献34

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二级参考文献23

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共引文献11

同被引文献62

  • 1刘增娟,董淑婷,段月鹏,杜淑娴.110例心力衰竭患者地高辛血药浓度监测及影响因素分析[J].中国药物应用与监测,2006,3(1):1-3. 被引量：17
  • 2周自强,胡大一,陈捷,张仁汉,李奎宝,赵秀丽.中国心房颤动现状的流行病学研究[J].中华内科杂志,2004,43(7):491-494. 被引量：1402
  • 3李景苏,蔡长春,侯艳宁.地高辛给药方案与血药浓度及临床疗效的关系[J].临床误诊误治,2006,19(1):3-5. 被引量：17
  • 4邹曼,刘伟斯.肝肾功能不全心衰患者地高辛血药浓度监测及个体化给药[J].医学信息（西安上半月）,2006,19(9):1620-1621. 被引量：4
  • 5陆辉志,徐亮.替考拉宁在血药浓度监测下临床应用一例[J].中华危重症医学杂志:电子版,2013,6(4):44-45.
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引证文献4

二级引证文献5

中国心脏起搏与心电生理杂志
2011年 第5期

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