氟比洛芬酯对鼻内镜手术围拔管期的躁动及疼痛影响

Efficacy of fluriprofen axetil injection on the analgesia and restlessness during the surround-extubate stage of endoscopic sinussurgery

目的观察预先静注氟比洛芬酯注射液对鼻内镜手术病人围拔管期躁动及术后疼痛的疗效。方法选择90例择期行鼻内镜手术患者,随机均分为3组:预先注射组(全麻诱导前,静脉注射氟比洛芬酯100 mg)、术后注射组(手术结束前,静脉注射氟比洛芬酯100 mg)及对照组(全麻诱导前,静脉注射生理盐水10 mL)。观察并记录各组的镇痛效果、躁动评分及不良反应发生率。结果预先静注氟比洛芬酯组,对躁动的控制效果显著强于术中注射组和对照组(P<0.05);于拔管后0.5,1,4 h,观察3组VAS评分差异有统计学意义(P<0.05);3组均有胃肠道副反应,但相比无统计学差异(P>0.05)。结论预先静注氟比洛芬酯对鼻内镜手术病人围拔管期躁动有良好的防治作用,且对于术后镇痛效果显著。

Objective To explore the effect of restlessness and post-surgical pain relief of flurbiprofen axetil for injection in the surround-extubate stage of endoscopic sinussurgery.Methods Ninety patients treated with endoscopic sinussurgery were divided into three groups randomly,theⅠgroup were injected 100 mg flurbiprofen axetil for injection before the operation,and theⅡgroup were treated with 100 mg flurbiprofen axetil for injection 30 mins before operations were over,and the Ⅲ group were injected 10 mL normal saline for injection before the operation.The effect of restlessness and post-surgical pain relief between the three groups were compared.Results The effect of restlessness management and post-surgical pain relief in the Ⅰ group are better than in the the other groups（P〈0.05）.Three groups have no statistics diference compared on gastrointestinal（P〈0.05）.Conclusion Injecting the flurbiprofen axetil in vein is effective and safe for restlessness management and post-surgical pain relief surround-extubate stage of endoscopic sinussurgery.