摘要
目的探讨婴幼儿手术前后血清皮质醇和IL-6水平的变化规律,分析两者在手术应激时的意义。方法取14例实体肿瘤择期手术患儿(3~6岁)术前24 h、术后4 h、术后24 h、术后48 h及术后72 h的血清,用免疫组织化学法和ELISA法检测皮质醇和IL-6表达水平。结果血清皮质醇和IL-6分别在术后24 h和4 h开始升高,并在术后72 h内降至术前水平。结论血清中皮质醇和IL-6的变化能反映人体对手术应激的耐受程度,可能作为推测实体肿瘤患儿术后恢复情况的敏感指标。
【Objective】 To observe the variation and regularity of cortisol and IL-6 in children blood serum pre and post operations,then analyze the role of these indexes in the surgical stress.【Methods】 The time to draw blood were at 24 hours pre-operation,4 hours,24 hours,48 hours,and 72 hours post-operation,then The expression of cortisol was detected by immunohistochemical method,and IL-6 by ELISA.【Results】 The blood serum of cortisol and IL-6 rise 24 hours post-operation and 4 hours post-operation,then decreased to pre-operation levels 72 hours post-operation.【Conclusions】 The change of cortisol and IL-6 in blood serum can reflex the ability of tolerance to operation,would be sensitive markers to presume and judge children's condition after operations.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第26期3299-3301,共3页
China Journal of Modern Medicine