摘要
目的:对比研究广东省江门、湛江、梅州、韶关四地所产南板蓝根解热、抗炎、免疫调节效应的异同。方法:观察上述来源南板蓝根对内毒素致发热大鼠体温,二甲苯致耳肿胀小鼠耳片肿胀度,大鼠棉球肉芽肿重量,环磷酰胺致小鼠免疫抑制脾脏、胸腺指数的影响。结果:江门、湛江、韶关产南板蓝根能显著降低发热大鼠的体温(P<0.05,P<0.01);四地所产南板蓝根均可显著降低小鼠耳肿胀度(P<0.01),湛江、韶关产南板蓝根均可显著降低大鼠棉球肉芽肿干重(P<0.01);韶关、湛江、江门产南板蓝根能提高小鼠脾脏指数(P<0.01),韶关、湛江产南板蓝根能提高小鼠胸腺指数(P<0.05,P<0.01)。四地所产南板蓝根的解热、抗炎、免疫调节综合效应强度为韶关>湛江>江门>梅州。结论:广东省四地所产南板蓝根均具有一定的解热、抗炎、免疫调节效应;其中以韶关产药理作用最强、梅州产最弱。
Objective. To observe the differences of antipyretic effects, anti-inflammation, immunoregulation of Radix Isatidis grown in Jiangmen, Zhanjiang, Meizhou, Shaoguan of Guangdong province. Methods: We observed the effects of Radix Isatidis grown in different places on body temperature of lipopolysaccharide (LPS)-induced fever rats, mice auricular edema induced by dimethylbenzene, the mass of tampon-induced granutoma in rats, and spleen index and thymus index in cyclophosphamide (CTX)-induced immunosuppression mice. Results: Radix Isatidis grown in Jiangmen, Zhanjiang, Shaoguan had obvious antipyretic effect on rats (P 〈 0.05 or P 〈 0.01), and Radix Isatidis from the four regions markedly reduced the auricular edema in mice (P 〈 0.01). Zhanjiang and Shaoguan Radix Isatidis could decrease dry weight of granuloma in rats (P 〈 0.01). Radix Isatidis grown in Shaoguan, Zhanjiang and Jiangmen could increase spleen index (P 〈 0.01), Shaoguan and Zhanjiang Radix Isatidis could increase thymus index (P 〈 0.05 or P 〈 0.01). The intensity of antipyretic effect, anti-inflammatory, immunoregulation of Radix Isatidis was in decreasing sequence in Shaoguan, Zhanjiang, Jiangmen and Meizhou. Conclusion: Radix Isatidis grown in Jiangmen, Zhanjiang, Meizhou, Shaoguan of Guangdong province has certain antipyretic effect, anti-inflammation and immunoregulation. Of them, Shaoguan Radix Isatidis has the best effect,, and Meizhou Radix Isatidis is the last one.
出处
《新中医》
CAS
北大核心
2011年第11期113-116,共4页
New Chinese Medicine
关键词
板蓝根
产地
解热
抗炎
免疫调节
动物实验
大鼠
小鼠
Radix Isatidis
Producing Area
Antipyretic Effects
Anti-inflammation
Immunoregulation
Animal Experiment
Rats
Mice