广东省不同产地南板蓝根解热、抗炎、免疫调节效应的对比研究

Comparative Study on Antipyretic Effects,Anti-inflammation,Immunoregulation of Radix Isatidis Grown in Different Regions of Guangdong Province

目的:对比研究广东省江门、湛江、梅州、韶关四地所产南板蓝根解热、抗炎、免疫调节效应的异同。方法:观察上述来源南板蓝根对内毒素致发热大鼠体温,二甲苯致耳肿胀小鼠耳片肿胀度,大鼠棉球肉芽肿重量,环磷酰胺致小鼠免疫抑制脾脏、胸腺指数的影响。结果:江门、湛江、韶关产南板蓝根能显著降低发热大鼠的体温(P<0.05,P<0.01);四地所产南板蓝根均可显著降低小鼠耳肿胀度(P<0.01),湛江、韶关产南板蓝根均可显著降低大鼠棉球肉芽肿干重(P<0.01);韶关、湛江、江门产南板蓝根能提高小鼠脾脏指数(P<0.01),韶关、湛江产南板蓝根能提高小鼠胸腺指数(P<0.05,P<0.01)。四地所产南板蓝根的解热、抗炎、免疫调节综合效应强度为韶关>湛江>江门>梅州。结论:广东省四地所产南板蓝根均具有一定的解热、抗炎、免疫调节效应;其中以韶关产药理作用最强、梅州产最弱。

Objective. To observe the differences of antipyretic effects, anti-inflammation, immunoregulation of Radix Isatidis grown in Jiangmen, Zhanjiang, Meizhou, Shaoguan of Guangdong province. Methods： We observed the effects of Radix Isatidis grown in different places on body temperature of lipopolysaccharide （LPS）-induced fever rats, mice auricular edema induced by dimethylbenzene, the mass of tampon-induced granutoma in rats, and spleen index and thymus index in cyclophosphamide （CTX）-induced immunosuppression mice. Results： Radix Isatidis grown in Jiangmen, Zhanjiang, Shaoguan had obvious antipyretic effect on rats （P 〈 0.05 or P 〈 0.01）, and Radix Isatidis from the four regions markedly reduced the auricular edema in mice （P 〈 0.01）. Zhanjiang and Shaoguan Radix Isatidis could decrease dry weight of granuloma in rats （P 〈 0.01）. Radix Isatidis grown in Shaoguan, Zhanjiang and Jiangmen could increase spleen index （P 〈 0.01）, Shaoguan and Zhanjiang Radix Isatidis could increase thymus index （P 〈 0.05 or P 〈 0.01）. The intensity of antipyretic effect, anti-inflammatory, immunoregulation of Radix Isatidis was in decreasing sequence in Shaoguan, Zhanjiang, Jiangmen and Meizhou. Conclusion： Radix Isatidis grown in Jiangmen, Zhanjiang, Meizhou, Shaoguan of Guangdong province has certain antipyretic effect, anti-inflammation and immunoregulation. Of them, Shaoguan Radix Isatidis has the best effect,, and Meizhou Radix Isatidis is the last one.