11C-蛋氨酸的制备及其正电子发射断层／CT显像

Preparation and application of 11C-methionine in PET / CT

目的研究新型脑肿瘤显像剂11C-蛋氨酸（11C-MET）的制备方法，探讨11C-MET的临床显像方法及其在脑肿瘤显像中的应用。方法回旋加速器轰击产生11C-CO2，甲醇化后获得反应活性很强的甲基化前体11C-CH3I，再与L-高胱氨酸硫内酯在常温下反应获得11C-MET。对1例脑胶质瘤术后患者进行PET／CT脑显像。结果11C-MET合成时间约2min，合成效率为85％，放射化学纯度〉99％，质量控制指标合格。结论11C-MET合成速度快，合成效率较高，适用于临床PET显像。11C-MET在脑肿瘤内有较长的滞留时间，有较高的肿瘤／脑比值，是理想的脑肿瘤显像剂。

Objective To study the preparation of 11C - MET and its clinical application in PET/CT for brain tumor. Methods By using the 11C- CO2 as the primary material from the cyclo- tron, an active reagent group 11C - CHaI can be made. PET/CT imaging with 11C - MET was per- formed in 1 patient with postoperation of brain gliomas. Results The synthesis time of 11C- MET was 2 rain, synthetic yield was 85% and radiochemical purity was over 99%. All quality criteria of 11C- MET meet the requirements of the positron radio - pharmaceuticals. Conclusions 11C - MET has high speed and high efficiency of synthesis; it can be used in PET imaging. 11C - MET showed high blood uptake and a long retention in the tumor mass, therefore can be a valuable tracer for PET/CT imaging of brain tumor.