原发性胆囊癌74例临床病理分析

Clinicopathologic analysis of 74 cases of primary gallbladder carcinomas

目的探讨原发性胆囊癌的临床病理特点。方法收集2000年至2010年我科原发性胆囊癌74例。全部病例经10％中性福尔马林固定，石蜡包埋切片，常规HE染色。结果病理组织学分型：高分化腺癌25例，占33．8％；中分化腺癌26例，占35．1％；低分化腺癌16例，占21．6％；鳞癌2例，占2．7％；黏液腺癌3例，占4．1％；印戒细胞癌2例，占2．7％。结论本组胆囊癌病理类型以腺癌为主，临床特点为起病隐匿，易浸润周围组织及转移，术前诊断困难，一般预后较差。

Objective To investigate the pathological classification and clinical features of primary gallbladder carcinoma. Methods To collect 74 cases of primary gallbladder carcinomas in our hospital from 2000 to 2010. All cases were in 10% neutral formalin - fixed, paraffin - embedded sections, routine HE staining. Results According to the newest tumor classification, 25 patients showed adeno- carcinoma with well differentiated （33.8%）, 26 cases showed adenocarcinoma of intermediated differenti- ation（35.1% ）, and 16 cases showed adenocarcinoma with poor differentiation（21.6% ）, 2 patients re- vealed squamous cell carcinoma （ accouting for 2.7 % ）, and 3 patients showed mucinous adeno carcinoma （4. 1% ）, signet - ring cell carcinoma in 2 cases （2. 7% ）. Conclusions The results showed that ade- nocarcinoma was the most common pathological type in gallbladder carcinoma, it always showed with high ability of infiltration and tendency of metastasis, it is difficult to diagnose before operating, the prognosis is very poor.