埃索美拉唑治疗反流性食管炎临床分析

Clinical analysis of esomeprazole in the treatment of refux esophagitis

目的探讨埃索美拉唑治疗反流性食管炎的临床疗效。方法将确诊的80例反流性食管炎患者分为治疗组和对照组，各40例。治疗组服用埃索美拉唑40mg，每日1次，对照组服用奥关拉唑40mg，每日1次，治疗4周后比较两组症状改善及治愈情况。结果经临床症状疗效观察，治疗组和对照组的愈显效率分别为72．5％和47．5％；内镜复查结果显示，治疗组愈显效率达92．5％，对照组愈显效率为80．0％。两组愈显效率比较差异有统计学意义（P〈0．05）。结论埃索美拉唑治疗反流性食管炎疗效显著，安全性较好。

Objective To investigate the clinical effects of esomeprazole in the treatment reflux esophagitis. Methods Eighty cases of reflux esophagitis were randomly divided into treatment group （40 cases） and control group （40 cases）. The treatment group was treated with esomeprazole 40 mg once daily. The control group was treated with omeprazole 40 mg once daily. After four weeks treatment, the two groups of symptoms alleviated and healing situation was compared. Results Observation of clinical symptoms showed that the healing significant efficiency of treatment group and control group were 72.5% and 47.5 % , respectively. Therefore, endoscope findings of the two groups were also investigated and their healing significant efficiency were 92.5% and 80.0% , respectively. There was significant differ- ence between the two groups （P 〈 0.05）. Conclusions Esomeprazole in the treatment of reflux esoph- agitis can achieve significant results as well as good security.