热毒宁注射液及安乃近注射液对成人急性上呼吸道感染的退热作用观察

Efficacy of Reduning and Analgin Injection in Fever-Relieving Caused by Acute Adult Upper Respiratory Tract Infections

目的探讨热毒宁注射液联合安乃近注射液治疗成人急性上呼吸道感染高热的效果。方法将960例急性上呼吸道感染高热的患者利用SPSS统计软件进行随机化实验分组,分3组进行回顾性分析。分别为热毒宁静滴+安乃近肌肉注射组、单用热毒宁静滴组、单用安乃近肌肉注射组,每组320例,观察测定治疗前、治疗后1 h、3 h的体温(口表)及不良反应。结果使用热毒宁静滴+安乃近肌肉注射组在治疗1 h后体温下降幅度较单用热毒宁静滴组大,差异有统计学意义(P<0.05),但和单用安乃近肌肉注射组疗效相当,差异无统计学意义(P>0.05),在治疗3 h后较单用热毒宁静滴组或安乃近肌肉注射组体温下降幅度大,差异有统计学意义(P<0.05);单用热毒宁静滴组在治疗3 h后体温下降幅度较单用安乃近肌肉注射组大,差异有统计学意义(P<0.05)。结论热毒宁注射液联合安乃近注射液治疗急性上呼吸道感染高热退热起效快,持续时间长,两种药物联合使用不良反应轻微。

Objective To observe the efficacy of Reduning and Analgin Injection in relieving high fever caused by acute upper respiratory tract infections in adult patients. Methods A total of 960 cases of high fever resulting from acute upper respiratory infections were divided into three groups and analyzed retrospectively.One group was treated with intravenous Reduning injection and intramuscular Analgin injection combined while the other two groups were treated with intravenous reduning injection and intramuscular Analgin injection alone,respectively.Each group included 320 cases.Body temperatures（oral） and adverse reactions were observed or measured before treatment and 1 h,3 h from the beginning of treatment. Results After one hour,decline of body temperature in the combined group was more remarkable than in the Reduning group（P0.05） and similar to that of the Analgin group（P0.05）.After three hours,decline of body temperature in the combined group was more remarkable than in both the Reduning and Analgin group（P0.05） and more remarkable in the Reduning group than in the Analgin group（P0.05）. Conclusion The curative effects of Reduning and Analgin injection combined is both quick-onset and prolonged,with minor adverse reactions.