胰母细胞瘤二例

Report of 2 cases of pancreatoblastoma

目的探讨胰母细胞瘤（PB）的诊断与治疗。方法回顾性分析海南省人民医院收治的2例PB资料。结果2例均为男性，年龄分别为11岁和8岁。肿瘤均为胰尾实性肿块，例1甲胎蛋白（AFP）正常。例2AFP2903ng／ml。2例均行胰尾切除术，术后病理诊断为PB。分别随访26和10个月，生存良好。结论PB多发生于男性儿童。胰腺部位实性肿块，同时伴有AFP明显升高时应考虑为PB；如无AFP升高也应警惕PB存在。手术切除是治疗PB的首选方法。

Objective To discuss the diagnosis and therapy of the pancreatoblastoma （PB）. Methods The data of 2 cases of PB were analyzed retrospectively and related literatures were reviewed. Results Both cases were males, 11 years old and 8 years old respectively. The 2 cases both had solid mass located in the tail of the pancreas. Alpha-fetal protein（AFP） was normal in case 1 and 2 903 ng/ml in case 2. The 2 cases underwent resection of the pancreas tail, and the postoperative pathological examination confirmed the diagnosis of PB. Followup of 26 months in case 1 and 10 months in case 2 showed that the survival was good. Conclusions PB is an extremely rare tumor of exocrine pancreas and often occurs in male children. The solid mass located in the pancreas with elevated AFP can be considered as PB. Our experience showed a pancreatic mass with normal AFP can also be PB. Surgery is the best management of PB.