黄鳝骨硫酸软骨素多糖降血脂功能研究

Study on lipid-decreasing effect of Chondroitin Sulfate Polysaccharides from monopterus albus bone

目的:观察黄鳝骨硫酸软骨素多糖(Chondroitin Sulfate Polysaccharides,CHS)对高脂小鼠的降血脂功能。方法:将经预处理后的黄鳝骨经碱提、酶解、过柱(大孔吸附树脂)、脱盐得到CHS,灌胃给高脂小鼠,研究其降血脂功能。结果:多糖低、中剂量组(9、27 mg/kg)与高脂模型组比较,能显著降低高脂小鼠血清总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平(P<0.01),对血清三酰甘油(TG)水平升高也有一定的抑制作用,但差异不显著;而高剂量组(81 mg/kg)仅能显著降低血清TC水平(P<0.05);各组对小鼠体重和腹部脂肪均影响不大。结论:27 mg/kg的CHS能显著降低高脂小鼠TC和LDL-C水平,并在一定程度上抑制小鼠TG水平的升高,具有一定降血脂功能。

Objective：To study the lipid-decreasing effect of Chondroitin Sulfate Polysaccharides（CHS）,which was extracted from monopterus albus bone on hyperlipidermia mice.Methods：CHS was extracted from pretreated monopterus albus bones by alkali-liquor extraction,enzyme decomposition,column separation and desalination.Then it was used on hyperlipidermia mice to observe the function of lipid-decreasing.Results：The total serum cholesterol（TC） and low-density lipoprotein（LDL-C） were very significantly decreased（P〈0.01） in the low and middle-dosage groups（9,27 mg/kg） compared with hyperlipidermia model group,and the rising of triglyceride（TG） was also be inhibited a little,but without distinct diversity;the TC level of the high-dosage group（81 mg/kg） could be obviously decreased（P〈0.05）;there had no effects on the weight and belly fat of mice of each groups.Conclusion：CHS（27 mg/kg） can decrease the TC and LDL-C level of hiperlipemia mice,inhibite the raisen of TG in a certain degree,and show some colesterol-lowering function.