雾化吸入肺表面活性物质在新生儿呼吸窘迫综合征治疗中的临床疗效研究

Clinical research of curative effect of atomization inhalation of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome

目的:观察雾化吸入肺表面活性物质在治疗新生儿呼吸窘迫综合征中的疗效。方法:筛选我院38例新生儿呼吸窘迫综合征患儿,分成实验组(n=22)与对照组(n=16),两组均给予常规综合治疗,实验组加用雾化吸入肺表面活性物质,观察治疗前后两组患儿肺功能的变化。结果:实验组临床总有效率、血气分析指标改变及并发症发生率明显优于对照组,差异均有统计学意义(均P<0.05);与治疗前比较,实验组治疗后患儿血氧分压明显升高,血二氧化碳分压明显降低,血pH逐渐恢复正常(均P<0.01)。结论:雾化吸入肺表面活性物质对新生儿呼吸窘迫综合征有显著疗效,能安全、有效、迅速改善患儿的氧气交换和肺部病变。

Objective：To observe the clinical effects of atomization inhalation of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome（NRDS）.Methods：38 patients of NRDS infants were divided into two groups.22 patients received curosurf which was one of the pulmonary surfactants were selected as experiment group,and 16 patients who did not received curosurf were selected as control group.All of other supportive treatments were the same in the both groups.The changes of the lung function were kept under observation after treatment.Results：In the experiment group,the clinical effective rate,blood gas analysis index change and the incidence of complications were significantly better than those in the control group（all P〈0.05）.Compared with before treatment,PaO2 in the experiment group after treatment was significantly higher,PaCO2 was significantly lower,and the pH value was also returned to normal gradually（all P〈0.01）.Conclusion：Atomization inhalation pulmonary surfactants has markedly effect in the treatment of neonatal respiratory distress syndrome,it can rapidly and effectively improve lung function and lung aeration.