纳洛酮治疗肺性脑病38例临床应用研究

Clinical application research of Naloxone in treatment of 38 cases of pulmonary encephalopathy

目的:探讨纳洛酮治疗慢性阻塞性肺病并发肺性脑病的临床疗效。方法:将76例肺性脑病患者随机分成治疗组和对照组,治疗组38例患者,给予纳洛酮首次0.4 mg加生理盐水20 ml静脉注射;然后纳洛酮0.8～2.0 mg+5%葡萄糖500 ml静脉滴注,1次/d;对照组38例患者给予尼可刹米1.5～2.25 g+5%葡萄糖500 ml静脉滴注,1次/d,观察疗效3 d。结果:治疗组30 min～3 d内患者血气指标大多数转为正常,患者的神志意识障碍得到了明显改善,有效率为94.74%,尼可刹米对照组有效率为76.31%,治疗组的有效率显著高于对照组,差异有统计学意义(P<0.05);纳洛酮应用期间无毒副作用发生。结论:纳洛酮治疗肺性脑病安全、经济、疗效确切。

Objective：To investigate clinical efficacy of Naloxone in treatment of chronic obstructive pulmonary disease（COPD） complicated by pulmonary encephalopathy.Methods：76 cases of pulmonary encephalopathy patients were randomly divided into treatment group（38 cases） and control group（38 cases）,treatment group was given Naloxone 0.4 mg ＋ 20 ml saline first iv,and 0.8～2.0 mg＋5% glucose 500 ml iv gtt qd,control group was given Nikethamide 1.5-2.25 g＋5% glucose 500 ml ivgtt qd.The effect was observed for 3 days.Results：The blood gas of Naloxone group changed to normal in 30 minutes to 3 days,the patient’s consciousness improved significantly,the efficiency rate of treatment group（94.74%） was significantly higher than that of control group（76.31%）,the difference was significant（P〈0.05）;there was no toxic side effects during the application of Naloxone.Conclusion：It is security,economic and effective of Naloxone in treatment of pulmonary encephalopathy.