抗-M抗体致交叉配血不合1例

One case of cross matching incompatibility induced by anti-M antibody

目的:对1例由于抗-M抗体导致交叉配血不合的情况进行临床检验和分析。方法:首先对患者进行直接抗人球蛋白试验,然后进行ABO血型系统、Rh血型系统、MNS血型系统血型鉴定,接着通过谱细胞对患者血清进行不规则抗体的筛选,最后通过吸收放散反应对抗-M抗体进行确证。结果:直接抗人球蛋白试验为阴性,血型为A型、Rh(+)、NN,导致凝聚胺交叉配血主侧凝聚的原因是存在不规则抗体,即抗-M抗体。结论:在临床工作中应该对不规则抗体的情况进行鉴别。对于交叉配血不合的结果,应该高度怀疑不规则抗体的存在,以避免溶血性输血反应的发生。

Objective：To perform clinical test and analysis of one case of cross matching incompatibility induced by anti-M antibody.Methods：Firstly the direct antiglobulin test was conducted,then ABO blood type,Rh blood type and MNS blood type were used to detect for patients.Serum irregular antibodies were detected through panel cells.Finally anti-M antibody was identified by absorption-release experiment.Results：Direct antiglobulin test result was negative and blood type was A,Rh（＋） and NN.The main cause of cross matching failure was identified to be the existence of irregular antibody,that was the anti-M antibody.Conclusion：We should identify the irregular antibody in clinical practice.When cross matching fails,we should highly suspect existence of irregular antibody in order to avoid hemolytic transfusion reactions.