可溶性转铁蛋白受体在慢性病贫血中的应用

The clinical application of soluble transferrin receptor in chronic anemia

目的:探讨可溶性转铁蛋白受体在慢性病贫血中的临床应用。方法:将63例慢性病贫血患者分为慢性病贫血缺铁组(30例)和慢性病贫血非缺铁组(33例),并选择同期23例健康体检者作为健康对照组。三组均采用生物素-亲和素-酶联免疫法定量检测可溶性转铁蛋白受体(sTFR)水平,并结合血清铁(SI)、铁蛋白(SF)、总铁结合力(TIBC)对结果进行分析比较。结果 :慢性病贫血缺铁组sTFR为(46.1±29.4)nmol/L,慢性病贫血非缺铁组sTFR为(18.4±5.7)nmol/L,健康对照组sTFR为(15.5±6.2)nmol/L,慢性病贫血缺铁组与其他两组比较,差异有统计学意义(P<0.01),慢性病贫血非缺铁组sTFR水平与正常组比较,差异无统计学意义(P>0.05)。结论:sTFR是一个灵敏、可靠的缺铁诊断的定量指标,在慢性病贫血人群的铁状况评估方面具有重要的临床价值。

Objective： To discuss the clinical application of soluble transferrin receptor in chronic anemia. Methods： 63 cases of patients with chronic anemia were divided into chronic anemia with iron deficiency group （30 cases） and chronic anemia without iron deficiency group （33 cases）, 23 cases of healthy person were divided into healty group. The concentration of sTFR was detected by the method of biotin-affinity grain enzyme-linked immunosorbent, and the results were comparison analyzed combination the level of TIBC, SI, SF. Results： The sTFR level of chronic anemia with iron deficiency group was （46.1±29.4） nmol/L; the sTFR level of chronic anemia without iron deficiency group was （18.4±5.7） nmol/L; the sTFR level of healty group was （15.5±6.2） nmol/L; the sTFR level of chronic anemia witb iron deficiency group were significantly higher than that of other groups （P〈0.01）; there was no significant difference between chronic anemia without iron deficiency group and healty group （P〉0.05）. Conclusion： sTFR is an sensitive and reliable quantitative index to diagnose iron deficiency.It has great clinical value in evaluation iron＇s situation of chronic anemia population.