摘要
目的探讨射频消融手术治疗对老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆同型半胱氨酸和血液流变学的影响。方法我院2009年6月～2011年3月确诊的老年OSAHS患者46例,通过射频消融手术治疗6个月后复查血浆同型半胱氨酸(Hcy)、全血黏度(低切变率、高切变率)、红细胞比容、纤维蛋白原并与术前对比。结果射频消融手术治疗6个月左右老年OSAHS患者Hcy、纤维蛋白原、红细胞比容、全血黏度低切变率、高切变率明显低于治疗前水平,差异有统计学意义(P<0.01或P<0.05)。经过手术后老年患者白天嗜睡、晨起头晕明显减轻,睡眠呼吸暂停低通气指数(AHI)显著降低,血氧饱和度明显提高,差异有统计学意义(P<0.01)。结论通过射频消融手术治疗可以改善老年OSAHS患者血浆同型半胱氨酸和血液流变学的指标,有可能降低老年OSAHS患者发生心脑血管疾病的危险性。
Objective To explore the effect of radiofrequency ablation surgery on plasma homocysteine and hemorheology in elderly patients with obstructive sleep apnea hypopnea syndrome （ OSAHS ）. Methods All 46 elderly patients with OSAHS were selected from June 2009 to March 2011 in our hospital. They were received the radiofrequency ablation surgery, the plasma homocysteine （Hcy）, whole blood viscosity （ low shear rate and high shear rate ）, hematocrit, fibrinogen were detected before and after 6 months of operation. Results The levels of plasma Hcy, hemorheology and AHI in post operation was significantly lower than that in preoperation, and the blood oxygen saturation obviously improved, there were statistical differences between before and after 6 months of operation （ P 〈 0.01 or P 〈 0.05 ）. Conclusion The radiofrequency ablation surgery can improve abnormity of plasma homocysteine and hemorheology in elderly patients with OSAHS and decrease the danger of cerebrovascular disorder.
出处
《中国现代医生》
2011年第29期12-13,15,共3页
China Modern Doctor
基金
浙江省老年医学学科群建设招标项目(2009ZB001)
