艾司西酞普兰联合小剂量喹硫平治疗抑郁症临床观察

Effects of Escitalopram Combined with Small Dose Quetiapne in Treatment of Depression:A Clinical Observation

目的观察艾司西酞普兰联合小剂量喹硫平治疗抑郁症的临床疗效。方法将80例抑郁症患者随机分成单用组与联用组各40例。于治疗前和治疗1、2、4、6、8周末采用汉密尔顿抑郁量表(HAMD)、HAMD中焦虑/躯体化和睡眠障碍2因子评分以及副反应量表(TESS)评价不良反应。结果联用组显效率86.8%,明显高于单用组66.7%,差异有统计虑/躯体化和睡眠障碍两因子评分方面比较差异有统计学意义(P<0.05);两组治疗期间TESS量表总分比较差异无统计学意义(P>0.05);两组不良反应发生率无统计学意义(P>0.05)。结论艾司西酞普兰联合小剂量喹硫平治疗抑郁症可以提高疗效,并迅速改善焦虑、躯体化症状和睡眠障碍。

Objective To observe the clinical efficacy of escitalopram combined with small dose quetiapine in treatment of depression. Methods Eighty depression patients were randomly divided into two groups ： Alone group and union group with 40 cases in each. Before treatmnet and at the first, second, fourth, sixth, eighth weekends efficacy were appraised with Hamilton despondent meter （ HAMD ） and the anxious/somzatization, sleep disorder of Hamilton despondent meter （ HAMD ）. the adverse reactions were appraised with the Treat Emergent Symptom Scale （TESS）. Results The union group significant efficiency, accounting for 86.8% were higher than the Alone group, accounting for66.7%, with a statistics significance （χ2=4-374, P 〈 0.05 ） ; the union group HAMD score was lower than the alone group at the first, second, fourth weekend obviously （P 〈 0.05）; after 2 groups＇ treatment, the comparison difference there was statistics significance in the anxious/somzatization and the sleep disorder score （ P 〈 0.05 ） ; there was no statistics significance in TESS score during 2 group treatment period （P 〉 0.05 ） ; there was no statistics significance in the incidence of two group adverse reactions （ P 〉 0.05 ）. Conclusion Escitalopram combined with small dose Quetiapne in treatment depression to be possible to enhance the efficacy, and rapidly improve the anxious, somzatization symptom and sleep disorder.